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SRPK1/2 and PP1alpha exert opposite functions by modulating SRSF1-guided MKNK2 alternative splicing in colon adenocarcinoma.
Liu H, Gong Z, Li K, Zhang Q, Xu Z, Xu Y. Liu H, et al. J Exp Clin Cancer Res. 2021 Feb 18;40(1):75. doi: 10.1186/s13046-021-01877-y. J Exp Clin Cancer Res. 2021. PMID: 33602301 Free PMC article.
Higher expression of SRPK1/2 or decreased activity of PP1alpha were responsible for enhancing SRSF1 phosphorylation and nucleus translocation, subsequently resulted in a switch of MKNK2 alternative splicing. CONCLUSIONS: Our data showed that phosphorylation and subc …
Higher expression of SRPK1/2 or decreased activity of PP1alpha were responsible for enhancing SRSF1 phosphorylation and nucleu …
USP39 promotes malignant proliferation and angiogenesis of renal cell carcinoma by inhibiting VEGF-A(165b) alternative splicing via regulating SRSF1 and SRPK1.
Pan XW, Xu D, Chen WJ, Chen JX, Chen WJ, Ye JQ, Gan SS, Zhou W, Song X, Shi L, Cui XG. Pan XW, et al. Cancer Cell Int. 2021 Sep 20;21(1):486. doi: 10.1186/s12935-021-02161-x. Cancer Cell Int. 2021. PMID: 34544400 Free PMC article.
The USP39 ((101-565)) fragment directly mediated its binding to SRSF1 and SRPK1, and promoted the phosphorylation of SRSF1 to regulate VEGF-A alternative splicing. ...CONCLUSION: USP39 acted as a pro-tumor factor by motivating the malignant biological process …
The USP39 ((101-565)) fragment directly mediated its binding to SRSF1 and SRPK1, and promoted the phosphorylation of SRSF1 …
Altered VEGF Splicing Isoform Balance in Tumor Endothelium Involves Activation of Splicing Factors Srpk1 and Srsf1 by the Wilms' Tumor Suppressor Wt1.
Wagner KD, El Maï M, Ladomery M, Belali T, Leccia N, Michiels JF, Wagner N. Wagner KD, et al. Cells. 2019 Jan 11;8(1):41. doi: 10.3390/cells8010041. Cells. 2019. PMID: 30641926 Free PMC article.
We analyzed VEGF isoforms, Wt1, Srpk1, and Srsf1 in normal and tumor endothelium. Wt1, Srpk1, Srsf1, and the angiogenic VEGF164a isoform were highly expressed in tumor endothelium compared to normal lung endothelium. ...Wt1(-KTS) directly binds and act …
We analyzed VEGF isoforms, Wt1, Srpk1, and Srsf1 in normal and tumor endothelium. Wt1, Srpk1, Srsf1, and the ang …
Abnormal expression of the pre-mRNA splicing regulators SRSF1, SRSF2, SRPK1 and SRPK2 in non small cell lung carcinoma.
Gout S, Brambilla E, Boudria A, Drissi R, Lantuejoul S, Gazzeri S, Eymin B. Gout S, et al. PLoS One. 2012;7(10):e46539. doi: 10.1371/journal.pone.0046539. Epub 2012 Oct 10. PLoS One. 2012. PMID: 23071587 Free PMC article.
Consistently, we further show that the SR-phosphorylating kinases SRPK1 and SRPK2 are upregulated in 92% and 94% of ADC as well as in 72% and 68% of SCC, respectively. ...Finally, we provide evidence that high levels of SRSF1 and P-SRSF2 proteins are associated with …
Consistently, we further show that the SR-phosphorylating kinases SRPK1 and SRPK2 are upregulated in 92% and 94% of ADC as well as in …
SRPK1 inhibition in vivo: modulation of VEGF splicing and potential treatment for multiple diseases.
Oltean S, Gammons M, Hulse R, Hamdollah-Zadeh M, Mavrou A, Donaldson L, Salmon AH, Harper SJ, Ladomery MR, Bates DO. Oltean S, et al. Biochem Soc Trans. 2012 Aug;40(4):831-5. doi: 10.1042/BST20120051. Biochem Soc Trans. 2012. PMID: 22817743 Review.
SRPK1 (serine-arginine protein kinase 1) is a protein kinase that specifically phosphorylates proteins containing serine-arginine-rich domains. ...VEGF (vascular endothelial growth factor), a principal angiogenesis factor contains an alternative 3' splice site in the termi …
SRPK1 (serine-arginine protein kinase 1) is a protein kinase that specifically phosphorylates proteins containing serine-arginine-ric …
Identification of a novel and potent small molecule inhibitor of SRPK1: mechanism of dual inhibition of SRPK1 for the inhibition of cancer progression.
Chandra A, Ananda H, Singh N, Qamar I. Chandra A, et al. Aging (Albany NY). 2020 Dec 3;13(1):163-180. doi: 10.18632/aging.202301. Epub 2020 Dec 3. Aging (Albany NY). 2020. PMID: 33291073 Free PMC article.
Protein kinases are the family of attractive enzyme targets for drug design with relevance to cancer biology. Serine arginine protein kinase 1 (SRPK1) is responsible for the phosphorylation of serine/arginine (SR)-rich proteins. ...Structural analysis of SRPK1 with …
Protein kinases are the family of attractive enzyme targets for drug design with relevance to cancer biology. Serine arginine protein kinase …
FGF-2 promotes angiogenesis through a SRSF1/SRSF3/SRPK1-dependent axis that controls VEGFR1 splicing in endothelial cells.
Jia T, Jacquet T, Dalonneau F, Coudert P, Vaganay E, Exbrayat-Héritier C, Vollaire J, Josserand V, Ruggiero F, Coll JL, Eymin B. Jia T, et al. BMC Biol. 2021 Aug 25;19(1):173. doi: 10.1186/s12915-021-01103-3. BMC Biol. 2021. PMID: 34433435 Free PMC article.
RESULTS: By combining 2D endothelial cells cultures, 3D collagen sprouting assay, a model of angiogenesis in cellulose sponges in mice and a model of angiogenesis in zebrafish, we collectively show that FGF-2 promotes proliferation, survival, and sprouting of endothelial cells by …
RESULTS: By combining 2D endothelial cells cultures, 3D collagen sprouting assay, a model of angiogenesis in cellulose sponges in mice and a …
Targeting alternative splicing as a new cancer immunotherapy-phosphorylation of serine arginine-rich splicing factor (SRSF1) by SR protein kinase 1 (SRPK1) regulates alternative splicing of PD1 to generate a soluble antagonistic isoform that prevents T cell exhaustion.
Wahid M, Pratoomthai B, Egbuniwe IU, Evans HR, Babaei-Jadidi R, Amartey JO, Erdelyi V, Yacqub-Usman K, Jackson AM, Morris JC, Patel PM, Bates DO. Wahid M, et al. Cancer Immunol Immunother. 2023 Dec;72(12):4001-4014. doi: 10.1007/s00262-023-03534-z. Epub 2023 Nov 16. Cancer Immunol Immunother. 2023. PMID: 37973660 Free PMC article.
RESULTS: The soluble form of PD-1, generated by skipping exon 3 (Ex3PD1), was endogenously expressed in PBMCs and T cells and prevents cancer cell-mediated T cell repression. Multiple binding sites of SRSF1 are adjacent to PD-1 exon 3 splicing sites. Overexpression of phos …
RESULTS: The soluble form of PD-1, generated by skipping exon 3 (Ex3PD1), was endogenously expressed in PBMCs and T cells and prevents cance …
Inhibition of serine/arginine-rich protein kinase-1 (SRPK1) prevents cholangiocarcinoma cells induced angiogenesis.
Supradit K, Boonsri B, Duangdara J, Thitiphatphuvanon T, Suriyonplengsaeng C, Kangsamaksin T, Janvilisri T, Tohtong R, Yacqub-Usman K, Grabowska AM, Bates DO, Wongprasert K. Supradit K, et al. Toxicol In Vitro. 2022 Aug;82:105385. doi: 10.1016/j.tiv.2022.105385. Epub 2022 May 11. Toxicol In Vitro. 2022. PMID: 35568131
SRPK1 has been reported to be overexpressed in multiple cancers, suggesting it as a promising therapeutic target in oncology. No previous studies reported the role of SRPK1 in cholangiocarcinoma (CCA) cells. This study aimed to examine the expression of SRPK1 …
SRPK1 has been reported to be overexpressed in multiple cancers, suggesting it as a promising therapeutic target in oncology. No prev …
Phosphorylation of SRSF1 by SRPK1 regulates alternative splicing of tumor-related Rac1b in colorectal cells.
Gonçalves V, Henriques AF, Pereira JF, Neves Costa A, Moyer MP, Moita LF, Gama-Carvalho M, Matos P, Jordan P. Gonçalves V, et al. RNA. 2014 Apr;20(4):474-82. doi: 10.1261/rna.041376.113. Epub 2014 Feb 18. RNA. 2014. PMID: 24550521 Free PMC article.
In colorectal cells, we found that depletion of AKT2, AKT3, GSK3beta, and SRPK1 significantly decreased endogenous Rac1b levels. Although knockdown of AKT2 and AKT3 affected only Rac1b protein levels suggesting a post-splicing effect, the depletion of GSK3beta or SRPK1 …
In colorectal cells, we found that depletion of AKT2, AKT3, GSK3beta, and SRPK1 significantly decreased endogenous Rac1b levels. Alth …
45 results